Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis

To study new target-oriented molecules that are active against rheumatoid arthritis-dependent pain, new dual inhibitors incorporating both a carbonic anhydrase (CA)-binding moiety and a cyclooxygenase inhibitor (NSAID) were tested in a rat model of rheumatoid arthritis induced by CFA intra-articular...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Micheli, Laura, Bozdag, Murat, Akgul, Ozlem, Carta, Fabrizio, Guccione, Clizia, Bergonzi, Maria Camilla, Bilia, Anna Rita, Cinci, Lorenzo, Lucarini, Elena, Parisio, Carmen, Supuran, Claudiu T., Ghelardini, Carla, Di Cesare Mannelli, Lorenzo
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514875/
https://ncbi.nlm.nih.gov/pubmed/31003542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20081923
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