A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities

Mycobacteriophages express various peptides/proteins to infect Mycobacterium tuberculosis (M. tb). Particular attention has been paid to mycobacteriophage-derived endolysin proteins. We herein characterized a small mycobacteriophage-derived peptide designated AK15 with potent anti-M. tb activity. AK...

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Publicat a:J Biol Chem
Autors principals: Yang, Yang, Liu, Zhen, He, Xiaoqin, Yang, Juanjuan, Wu, Jing, Yang, Hailong, Li, Min, Qian, Qian, Lai, Ren, Xu, Wei, Wei, Lin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514635/
https://ncbi.nlm.nih.gov/pubmed/30894414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006968
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