Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways

Dysregulation of the enzymes involved in the pentose phosphate pathway (PPP) is known to promote tumorigenesis. Our recent study demonstrated that ribose-5-phosphate isomerase (RPIA), a key regulator of the PPP, regulates hepatoma cell proliferation and colony formation. Our studies in zebrafish rev...

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Vydáno v:Carcinogenesis
Hlavní autoři: Chou, Yu-Ting, Chen, Li-Yang, Tsai, Shin-Lin, Tu, Hsiao-Chen, Lu, Jeng-Wei, Ciou, Shih-Ci, Wang, Horng-Dar, Yuh, Chiou-Hwa
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Carcinogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514454/
https://ncbi.nlm.nih.gov/pubmed/30418535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy155
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