Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency

Testicular teratomas result from anomalies in embryonic germ cell development. In 129 inbred mice, teratoma initiation coincides with germ cell sex-specific differentiation and the mitotic-meiotic switch: XX and XY germ cells repress pluripotency, XX germ cells initiate meiosis, and XY germ cells ac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Development
Hauptverfasser: Dawson, Emily P., Lanza, Denise G., Webster, Nicholas J., Benton, Susan M., Suetake, Isao, Heaney, Jason D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514421/
https://ncbi.nlm.nih.gov/pubmed/29545285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.156612
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