Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors

Expression of the ALK gene strongly correlates with the WNT-activated medulloblastomas, which are routinely identified by detection of CTNNB1 mutation. However, some tumors have mutations in other than CTNNB1 genes. Therefore, we investigated if ALK expression may identify WNT-activated tumors witho...

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Dettagli Bibliografici
Pubblicato in:Brain Tumor Pathol
Autori principali: Łastowska, Maria, Trubicka, Joanna, Karkucińska-Więckowska, Agnieszka, Kaleta, Magdalena, Tarasińska, Magdalena, Perek-Polnik, Marta, Sobocińska, Anna Antonina, Dembowska-Bagińska, Bożenna, Grajkowska, Wiesława, Matyja, Ewa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Singapore 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514113/
https://ncbi.nlm.nih.gov/pubmed/30523493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10014-018-0331-2
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