Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis

BACKGROUND: B7-H3 (CD276), part of the B7 superfamily of immune checkpoint molecules, has been shown to have an immunomodulatory role. Its regulation, receptor and mechanism of action remain unclear. B7-H3 protein expression correlates with prostate cancer outcomes, and humanized monoclonal antibodi...

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Veröffentlicht in:Prostate Cancer Prostatic Dis
Hauptverfasser: Benzon, B, Zhao, SG, Haffner, MC, Takhar, M, Erho, N, Yousefi, K, Hurley, P, Bishop, JL, Tosoian, J, Ghabili, K, Alshalalfa, M, Glavaris, S, Simons, BW, Tran, P, Davicioni, E, Karnes, RJ, Boudadi, K, Antonarakis, ES, Schaeffer, EM, Drake, CG, Feng, F, Ross, AE
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512966/
https://ncbi.nlm.nih.gov/pubmed/27801901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pcan.2016.49
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