Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): functional heterogeneity of the enzyme and the reversibility of its inactivation

We investigate the mechanism of time-dependent inhibition (TDI) of human cytochrome P450 2D6 (CYP2D6) by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), one of the most widespread recreational drugs of abuse. In an effort to unravel the kinetic mechanism of the formation of metabolic inhibitory c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biochem Pharmacol
Auteurs principaux: Rodgers, John T., Davydova, Nadezhda Y., Paragas, Erickson M., Jones, Jeffrey P., Davydov, Dmitri R.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512342/
https://ncbi.nlm.nih.gov/pubmed/30114388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.08.010
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