NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance

Tc-DNA is a conformationally constrained oligonucleotide analogue which shows significant increase in thermal stability when hybridized with RNA, DNA or tc-DNA. Remarkably, recent studies revealed that tc-DNA antisense oligonucleotides (AO) hold great promise for the treatment of Duchenne muscular d...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Istrate, Andrei, Johannsen, Silke, Istrate, Alena, Sigel, Roland K O, Leumann, Christian J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511864/
https://ncbi.nlm.nih.gov/pubmed/30916334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz197
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