Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer

Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising targeted therapies for BRCA-mutated cancers by blocking repair of DNA double-strand breaks. However, resistance to PARP inhibitors (PARPi) has been described in some patients lowering the overall response rates. To investigate...

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Pubblicato in:Am J Cancer Res
Autori principali: Han, Ye, Li, Chia-Wei, Hsu, Jung-Mao, Hsu, Jennifer L, Chan, Li-Chuan, Tan, Xiaodong, He, Gui-Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511636/
https://ncbi.nlm.nih.gov/pubmed/31106005
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