Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery

BACKGROUND: Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery...

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Published in:Circulation
Main Authors: Aragam, Krishna G., Chaffin, Mark, Levinson, Rebecca T., McDermott, Gregory, Choi, Seung-Hoan, Shoemaker, M. Benjamin, Haas, Mary E., Weng, Lu-Chen, Lindsay, Mark E., Smith, J. Gustav, Newton-Cheh, Christopher, Roden, Dan M., London, Barry, Wells, Quinn S., Ellinor, Patrick T., Kathiresan, Sekar, Lubitz, Steven A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511334/
https://ncbi.nlm.nih.gov/pubmed/30586722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.035774
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