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DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria

Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved in DNA repair in both single and double strand break repair systems. Mutations...

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Bibliografische gegevens
Gepubliceerd in:Transl Neurodegener
Hoofdauteurs: Bermúdez-Guzmán, Luis, Leal, Alejandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511134/
https://ncbi.nlm.nih.gov/pubmed/31110700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0156-x
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