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Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity
Second messenger molecules play important roles in the responses to various stimuli that can determine a cell's fate under stress conditions. Here, we report that lethal concentrations of aminoglycoside antibiotics result in the production of a dinucleotide alarmone metabolite–diadenosine tetra...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511005/ https://ncbi.nlm.nih.gov/pubmed/31004054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1822026116 |
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