Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural cells. We identified ZIKV host genes in human pluripotent stem cell (hPSC)-der...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Li, Yun, Muffat, Julien, Omer Javed, Attya, Keys, Heather R., Lungjangwa, Tenzin, Bosch, Irene, Khan, Mehreen, Virgilio, Maria C., Gehrke, Lee, Sabatini, David M., Jaenisch, Rudolf
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510995/
https://ncbi.nlm.nih.gov/pubmed/31019072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900867116
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