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Tissue-specific genes as an underutilized resource in drug discovery
Tissue-specific genes are believed to be good drug targets due to improved safety. Here we show that this intuitive notion is not reflected in phase 1 and 2 clinical trials, despite the historic success of tissue-specific targets and their 2.3-fold overrepresentation among targets of marketed non-on...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6510781/ https://ncbi.nlm.nih.gov/pubmed/31076736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43829-9 |
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