Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

BACKGROUND: Studies have shown that both NOX4 and RhoA play essential roles in fibrosis and that they regulate each other. In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis. Currently, no reports have in...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Huang, Chenkai, Gan, Dakai, Luo, Fangyun, Wan, Sizhe, Chen, Jiang, Wang, Anjiang, Li, Bimin, Zhu, Xuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510285/
https://ncbi.nlm.nih.gov/pubmed/31130857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00431
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