MD-SVM: a novel SVM-based algorithm for the motif discovery of transcription factor binding sites

BACKGROUND: Transcription factors (TFs) play important roles in the regulation of gene expression. They can activate or block transcription of downstream genes in a manner of binding to specific genomic sequences. Therefore, motif discovery of these binding preference patterns is of central signific...

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Udgivet i:BMC Bioinformatics
Main Authors: Hu, Jialu, Wang, Jingru, Lin, Jianan, Liu, Tianwei, Zhong, Yuanke, Liu, Jie, Zheng, Yan, Gao, Yiqun, He, Junhao, Shang, Xuequn
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509868/
https://ncbi.nlm.nih.gov/pubmed/31074373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2735-3
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