Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 in Pneumocystis carinii

Rtt109 is a histone acetyltransferase (HAT) that is a potential therapeutic target in conditioned pathogenic fungi Pneumocystis carinii (P. carinii). The histone chaperone Vps75 can stimulate the Rtt109-dependent acetylation of several histone H3 lysines and preferentially acetylates H3K9 and H3K27...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Chen, Yiping, Zhang, Yang, Ye, Hui, Dou, Yanshu, Lu, Deren, Li, Xiaolu, Limper, Andrew H., Han, Junhong, Su, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509256/
https://ncbi.nlm.nih.gov/pubmed/31098304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0047-8
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