The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release

The neuronal loss caused by excessive glutamate release, or ‘excitotoxicity’, leads to several pathological conditions, including cerebral ischemia, epilepsy, and neurodegenerative diseases. Over-stimulation of presynaptic N-methyl-D-aspartate (NMDA) receptors is known to trigger and support glutama...

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Publicado no:Sci Rep
Main Authors: Marcelli, Serena, Iannuzzi, Filomena, Ficulle, Elena, Mango, Dalila, Pieraccini, Stefano, Pellegrino, Sara, Corbo, Massimo, Sironi, Maurizio, Pittaluga, Anna, Nisticò, Robert, Feligioni, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509125/
https://ncbi.nlm.nih.gov/pubmed/31073146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43709-2
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