PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells

OBJECTIVES: This study aimed at investigating the molecular mechanism underlying PKM2-mediated cancer invasion. MATERIALS & METHODS: To optimize the investigation of PKM2-specific effects, we used two immortalized oral cell lines. The two cell lines drastically differed in PKM2 expression level,...

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Vydáno v:PLoS One
Hlavní autoři: Park, Young-Jin, Kim, Jue Young, Lee, Doo Young, Zhang, Xianglan, Bazarsad, Shadavlonjid, Chung, Won-Yoon, Kim, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508653/
https://ncbi.nlm.nih.gov/pubmed/31071178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216661
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