Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation

Malignant glioma is one of the most common types of primary malignancies in the human central nervous system. Temozolomide (TMZ) is the most commonly used drug in clinical therapy of glioma; however, chemoresistance makes glioma difficult to cure and relapse likely. Sirtuin 1 (SIRT1) serves importan...

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Gepubliceerd in:Oncol Lett
Hoofdauteurs: Chen, Hongwu, Lin, Rui, Zhang, Ziheng, Wei, Quantang, Zhong, Zhiwei, Huang, Jiehao, Xu, Yimin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507466/
https://ncbi.nlm.nih.gov/pubmed/31186751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10235
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