Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With Chronic Obstructive Pulmonary Disease: The ASCENT-COPD Randomized Clinical Trial

IMPORTANCE: There is concern that long-acting muscarinic antagonists increase cardiovascular morbidity or mortality in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: To determine the cardiovascular safety (noninferiority) and efficacy (superiority) of aclidinium bromide, 400...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Wise, Robert A., Chapman, Kenneth R., Scirica, Benjamin M., Bhatt, Deepak L., Daoud, Sami Z., Zetterstrand, Sofia, Reisner, Colin, Gil, Esther Garcia
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506885/
https://ncbi.nlm.nih.gov/pubmed/31063575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.4973
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