Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome

PURPOSE: CALGB/SWOG 80405 was a randomized phase III trial that found no statistically significant difference in overall survival (OS) in patients with first-line metastatic colorectal cancer treated with chemotherapy plus either bevacizumab or cetuximab. Primary tumor DNA from 843 patients has been...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Innocenti, Federico, Ou, Fang-Shu, Qu, Xueping, Zemla, Tyler J., Niedzwiecki, Donna, Tam, Rachel, Mahajan, Shilpi, Goldberg, Richard M., Bertagnolli, Monica M., Blanke, Charles D., Sanoff, Hanna, Atkins, James, Polite, Blasé, Venook, Alan P., Lenz, Heinz-Josef, Kabbarah, Omar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506418/
https://ncbi.nlm.nih.gov/pubmed/30865548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.01798
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