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DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells
Human cells lacking DNA polymerase η (polη) are sensitive to platinum-based cancer chemotherapeutic agents. Using DNA combing to directly investigate the role of polη in bypass of platinum-induced DNA lesions in vivo, we demonstrate that nascent DNA strands are up to 39% shorter in human cells lacki...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505966/ https://ncbi.nlm.nih.gov/pubmed/24253929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03277 |
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