Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: Up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers

In liver fibrosis, conversion of fibroblasts to profibrogenic myofibroblasts significantly drives the development of the disease. A crucial role of cyclic adenosine monophosphate (cAMP) in regulation of fibroblast function has been reported. Increase in cAMP levels has been found to decrease fibrobl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: El Awdan, Sally A., Abdel Rahman, Rehab F., Ibrahim, Heba M., Hegazy, Rehab R., El Marasy, Salma A., Badawi, Manal, Arbid, Mahmoud S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505801/
https://ncbi.nlm.nih.gov/pubmed/31067255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216301
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