Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7

Nuclear and mitochondrial genome mutations lead to various mitochondrial diseases, many of which affect the mitochondrial respiratory chain. The proteome of the intermembrane space (IMS) of mitochondria consists of several important assembly factors that participate in the biogenesis of mitochondria...

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Bibliografiska uppgifter
I publikationen:EMBO Mol Med
Huvudupphovsmän: Mohanraj, Karthik, Wasilewski, Michal, Benincá, Cristiane, Cysewski, Dominik, Poznanski, Jaroslaw, Sakowska, Paulina, Bugajska, Zaneta, Deckers, Markus, Dennerlein, Sven, Fernandez‐Vizarra, Erika, Rehling, Peter, Dadlez, Michal, Zeviani, Massimo, Chacinska, Agnieszka
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505684/
https://ncbi.nlm.nih.gov/pubmed/30885959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809561
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