Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis

BACKGROUND/AIMS: The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending on their CYP3A5 expression status. Here, we ev...

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Bibliografiske detaljer
Udgivet i:Intest Res
Main Authors: Okabayashi, Shinji, Kobayashi, Taku, Saito, Eiko, Toyonaga, Takahiko, Ozaki, Ryo, Sagami, Shintaro, Nakano, Masaru, Tanaka, Junichi, Yagisawa, Keiji, Kuronuma, Satoshi, Takeuchi, Osamu, Hibi, Toshifumi
Format: Artigo
Sprog:Inglês
Udgivet: Korean Association for the Study of Intestinal Diseases 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505090/
https://ncbi.nlm.nih.gov/pubmed/30704156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5217/ir.2018.00117
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