Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice

GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including Foxj1 and Ccno. Male mice that lacked Gemc1, Mcidas or Ccno were found to be infertile, but the origin of this defect has remained unclear. Here, we show that all thre...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Development
Päätekijät: Terré, Berta, Lewis, Michael, Gil-Gómez, Gabriel, Han, Zhiyuan, Lu, Hao, Aguilera, Mònica, Prats, Neus, Roy, Sudipto, Zhao, Haotian, Stracker, Travis H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2019
Aiheet:
Research Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503982/
https://ncbi.nlm.nih.gov/pubmed/30936178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162628
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