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Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors

Valproic acid (VPA) is a well-established therapeutic used in treatment of seizure and mood disorders as well as migraines and a known hepatotoxicant. About 50% of VPA users experience metabolic disruptions, including weight gain, hyperlipidemia, and hyperinsulinemia, among others. Several of these...

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Dettagli Bibliografici
Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Griggs, Chanel A., Malm, Scott W., Jaime-Frias, Rosa, Smith, Catharine L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503860/
https://ncbi.nlm.nih.gov/pubmed/29229235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.12.005
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