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Estimation of Study Time Reduction Using Surrogate End Points Rather Than Overall Survival in Oncology Clinical Trials
IMPORTANCE: Surrogate end points in oncology trade the advantage of reducing the time needed to conduct clinical trials for the disadvantage of greater uncertainty regarding the treatment effect on patient-centered end points, such as overall survival (OS) and quality of life. OBJECTIVE: To quantify...
Gardado en:
| Publicado en: | JAMA Intern Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Medical Association
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503556/ https://ncbi.nlm.nih.gov/pubmed/30933235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamainternmed.2018.8351 |
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