CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

BACKGROUND: Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and chemoresistance have not been fully characterized. METHODS: CAFs and NFs were obt...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Hu, J. L., Wang, W., Lan, X. L., Zeng, Z. C., Liang, Y. S., Yan, Y. R., Song, F. Y., Wang, F. F., Zhu, X. H., Liao, W. J., Liao, W. T., Ding, Y. Q., Liang, L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503554/
https://ncbi.nlm.nih.gov/pubmed/31064356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1019-x
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