Use of PBPK Modeling To Evaluate the Performance of DissolvIt, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products

[Image: see text] The dissolution of inhaled drug particles in the lungs is a challenge to model using biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and dose, (ii) presenting this to a small volume of medium that is representative of lung lining fluid, and (iii...

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Bibliografske podrobnosti
izdano v:Mol Pharm
Main Authors: Hassoun, Mireille, Malmlöf, Maria, Scheibelhofer, Otto, Kumar, Abhinav, Bansal, Sukhi, Selg, Ewa, Nowenwik, Mattias, Gerde, Per, Radivojev, Snezana, Paudel, Amrit, Arora, Sumit, Forbes, Ben
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503535/
https://ncbi.nlm.nih.gov/pubmed/30640475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b01200
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