Acute-on-chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries through enhanced PKA, PI3K/AKT and cGMP signalling pathways

Acute-on-chronic liver disease is a clinical syndrome characterized by decompensated liver fibrosis, portal hypertension and splanchnic hyperdynamic circulation. We aimed to determine whether the alpha-1 agonist phenylephrine (Phe) facilitates endothelial nitric oxide (NO) release by mesenteric resi...

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Vydáno v:Sci Rep
Hlavní autoři: Caracuel, Laura, Sastre, Esther, Llévenes, Pablo, Prieto, Isabel, Funes, Tania, Aller, Mª Ángeles, Arias, Jaime, Balfagón, Gloria, Blanco-Rivero, Javier
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502824/
https://ncbi.nlm.nih.gov/pubmed/31061522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43513-y
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