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LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype

Reactivation of interspersed repetitive sequences due to loss of methylation is associated with genomic instability, one of the hallmarks of cancer cells. LINE-1 hypomethylation is a surrogate marker for global methylation loss and is potentially a new diagnostic and prognostic biomarker in tumors....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Anwar, Sumadi Lukman, Hasemeier, Britta, Schipper, Elisa, Vogel, Arndt, Kreipe, Hans, Lehmann, Ulrich
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502450/
https://ncbi.nlm.nih.gov/pubmed/31059558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216374
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