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LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype

Reactivation of interspersed repetitive sequences due to loss of methylation is associated with genomic instability, one of the hallmarks of cancer cells. LINE-1 hypomethylation is a surrogate marker for global methylation loss and is potentially a new diagnostic and prognostic biomarker in tumors....

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Anwar, Sumadi Lukman, Hasemeier, Britta, Schipper, Elisa, Vogel, Arndt, Kreipe, Hans, Lehmann, Ulrich
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502450/
https://ncbi.nlm.nih.gov/pubmed/31059558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216374
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