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Revealing evolutionary constraints on proteins through sequence analysis

Statistical analysis of alignments of large numbers of protein sequences has revealed “sectors” of collectively coevolving amino acids in several protein families. Here, we show that selection acting on any functional property of a protein, represented by an additive trait, can give rise to such a s...

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Udgivet i:PLoS Comput Biol
Main Authors: Wang, Shou-Wen, Bitbol, Anne-Florence, Wingreen, Ned S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502352/
https://ncbi.nlm.nih.gov/pubmed/31017888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007010
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