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Revealing evolutionary constraints on proteins through sequence analysis
Statistical analysis of alignments of large numbers of protein sequences has revealed “sectors” of collectively coevolving amino acids in several protein families. Here, we show that selection acting on any functional property of a protein, represented by an additive trait, can give rise to such a s...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502352/ https://ncbi.nlm.nih.gov/pubmed/31017888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007010 |
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