Predicting Drug–Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling

BACKGROUND: Cabotegravir and rilpivirine are 2 long-acting (LA) antiretrovirals that can be administered intramuscularly; their interaction with rifampicin, a first-line antituberculosis agent, has not been investigated. The aim of this study was to simulate and predict drug–drug interactions (DDIs)...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Rajoli, Rajith K R, Curley, Paul, Chiong, Justin, Back, David, Flexner, Charles, Owen, Andrew, Siccardi, Marco
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500558/
https://ncbi.nlm.nih.gov/pubmed/30566691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy726
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