Mesenchymal niche-specific expression of Cxcl12 controls quiescence of treatment-resistant leukemia stem cells

Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the BCR-ABL oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs). TKIs do not eliminate disease-propagating leukemic stem cells (LSC), suggesting a deeper understanding of niche-dependen...

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Publicat a:Cell Stem Cell
Autors principals: Agarwal, Puneet, Isringhausen, Stephan, Li, Hui, Paterson, Andrew J., He, Jianbo, Gomariz, Álvaro, Nagasawa, Takashi, Nombela-Arrieta, César, Bhatia, Ravi
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499704/
https://ncbi.nlm.nih.gov/pubmed/30905620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.02.018
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