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Analysis of Control Arm Quality in Randomized Clinical Trials Leading to Anticancer Drug Approval by the US Food and Drug Administration

IMPORTANCE: To date, an empirical evaluation of the quality of control arms in randomized clinical trials (RCTs) leading to anticancer drug approvals by the US Food and Drug Administration (FDA) has not been undertaken. OBJECTIVE: We sought to estimate the percentage of RCTs that used a control arm...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Hilal, Talal, Sonbol, Mohamad Bassam, Prasad, Vinay
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499129/
https://ncbi.nlm.nih.gov/pubmed/31046071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.0167
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