Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression

Traumatic brain injury (TBI) is a frequent pathology associated with poor neurological outcome in the aged population. We recently observed accelerated cerebral inflammation in aged mice in response to TBI. Candesartan is a potent specific inhibitor of angiotensin II receptor type 1 (AT1) which limi...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Timaru-Kast, Ralph, Gotthardt, Philipp, Luh, Clara, Huang, Changsheng, Hummel, Regina, Schäfer, Michael K. E., Thal, Serge C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499023/
https://ncbi.nlm.nih.gov/pubmed/31105549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00063
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