Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers. However, resistance observed in both pre-clinical...

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Udgivet i:Oncotarget
Main Authors: Ordonez, Liliana D., Hay, Trevor, McEwen, Robert, Polanska, Urszula M., Hughes, Adina, Delpuech, Oona, Cadogan, Elaine, Powell, Steve, Dry, Jonathan, Tornillo, Giusy, Silcock, Lucy, Leo, Elisabetta, O’Connor, Mark J., Clarke, Alan R., Smalley, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498996/
https://ncbi.nlm.nih.gov/pubmed/31080552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26830
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