Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques

Most human immunodeficiency virus type 1 (HIV-1) infections begin at mucosal surfaces. Providing a barrier of protection at these may assist in combating the earliest events in infection. Systemic immunization by intramuscular (i.m.) injection can drive mucosal immune responses, but there are data s...

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Vydáno v:J Virol
Hlavní autoři: Matchett, William E., Anguiano-Zarate, Stephanie S., Nehete, Pramod N., Shelton, Kathryn, Nehete, Bharti P., Yang, Guojun, Dorta-Estremera, Stephanie, Barnette, Philip, Xiao, Peng, Byrareddy, Siddappa N., Villinger, Francois, Hessell, Ann J., Haigwood, Nancy L., Sastry, K. Jagannadha, Barry, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498041/
https://ncbi.nlm.nih.gov/pubmed/30842321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02016-18
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