Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

Amyloid-β (Aβ) pathology in Alzheimer's disease (AD) is characterized by the formation of polymorphic deposits comprising diffuse and cored plaques. Because diffuse plaques are predominantly observed in cognitively unaffected, amyloid-positive (CU-AP) individuals, pathogenic conversion into cor...

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Publicado en:J Biol Chem
Autores principales: Michno, Wojciech, Nyström, Sofie, Wehrli, Patrick, Lashley, Tammaryn, Brinkmalm, Gunnar, Guerard, Laurent, Syvänen, Stina, Sehlin, Dag, Kaya, Ibrahim, Brinet, Dimitri, Nilsson, K. Peter R., Hammarström, Per, Blennow, Kaj, Zetterberg, Henrik, Hanrieder, Jörg
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497931/
https://ncbi.nlm.nih.gov/pubmed/30814252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006604
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