An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

FINDINGS: Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Detaille, Dominique, Pasdois, Philippe, Sémont, Audrey, Dos Santos, Pierre, Diolez, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497312/
https://ncbi.nlm.nih.gov/pubmed/31048932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216385
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