Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome

The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with s...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Thorpe, James H., Edgar, Emma V., Smith, Kathrine J., Lewell, Xiao Q., Rella, Monika, White, Gemma V., Polyakova, Oxana, Nassau, Pamela, Walker, Ann L., Holmes, Duncan S., Pearce, Andrew C., Wang, Yichen, Liddle, John, Hovnanian, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2019
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497096/
https://ncbi.nlm.nih.gov/pubmed/31045568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19003169
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