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Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF‐7 and MDA‐MB‐468

OBJECTIVES: Phosphodiesterase 9 (PDE9) is a major isoform of phosphodiesterase hydrolysing cGMP and plays a key role in proliferation of cells, their differentiation and apoptosis, via intracellular cGMP signalling. The study described here was designed to investigate expression, activity and apopto...

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Detalles Bibliográficos
Publicado en:Cell Prolif
Main Authors: Saravani, R., Karami‐Tehrani, F., Hashemi, M., Aghaei, M., Edalat, R.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496613/
https://ncbi.nlm.nih.gov/pubmed/22469131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2012.00819.x
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