A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide‐induced granulocytopaenia

Objectives:  Recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) is widely used as treatment for granulocytopaenia during cytotoxic chemotherapy; however, optimal scheduling of this pharmaceutical is unknown. Biomathematical models can help to pre‐select optimal application schedules b...

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Bibliographic Details
Published in:Cell Prolif
Main Authors: Scholz, M., Ackermann, M., Engel, C., Emmrich, F., Loeffler, M., Kamprad, M.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2009
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496189/
https://ncbi.nlm.nih.gov/pubmed/19689472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2009.00638.x
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