In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis

The riminophenazine agent clofazimine (CFZ) is repurposed as an important component of the new short-course multidrug-resistant tuberculosis regimen and significantly shortens first-line regimen for drug-susceptible tuberculosis in mice. However, CFZ use is hampered by its unwelcome skin discolorati...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Xu, Jian, Wang, Bin, Fu, Lei, Zhu, Hui, Guo, Shaochen, Huang, Haihong, Yin, Dali, Zhang, Ye, Lu, Yu
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496038/
https://ncbi.nlm.nih.gov/pubmed/30782992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02155-18
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