Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor

Microcin C (McC) is a peptide adenylate antibiotic produced by Escherichiacoli cells bearing a plasmid-borne mcc gene cluster. Most MccA precursors, encoded by validated mcc operons from diverse bacteria, are 7 amino acids long, but the significance of this precursor length conservation has remained...

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Veröffentlicht in:mBio
Hauptverfasser: Zukher, Inna, Pavlov, Michael, Tsibulskaya, Darya, Kulikovsky, Alexey, Zyubko, Tatyana, Bikmetov, Dmitry, Serebryakova, Marina, Nair, Satish K., Ehrenberg, Måns, Dubiley, Svetlana, Severinov, Konstantin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495379/
https://ncbi.nlm.nih.gov/pubmed/31040244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00768-19
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