Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation

Universal proteomics sample preparation is challenging because of the high heterogeneity of biological samples. Here we describe a novel mechanism that exploits the inherent instability of denatured proteins for nonspecific immobilization on microparticles by protein aggregation capture. To demonstr...

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Udgivet i:Mol Cell Proteomics
Main Authors: Batth, Tanveer S., Tollenaere, Maxim A. X., Rüther, Patrick, Gonzalez-Franquesa, Alba, Prabhakar, Bhargav S., Bekker-Jensen, Simon, Deshmukh, Atul S., Olsen, Jesper V.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2019
Fag:
Technological Innovation and Resources
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495262/
https://ncbi.nlm.nih.gov/pubmed/30833379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR118.001270
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