Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab

Introduction: Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been demonstrated. The aim of the study is to analyze B...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Regola, Francesca, Piantoni, Silvia, Lowin, Torsten, Archetti, Silvia, Reggia, Rossella, Kumar, Rajesh, Franceschini, Franco, Airò, Paolo, Tincani, Angela, Andreoli, Laura, Pongratz, Georg
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494924/
https://ncbi.nlm.nih.gov/pubmed/31105569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00433
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