Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and cellular structural remodeling in the form of disorganization and loss of the transverse tubule network. Indeed, survival rates for HF are worse than many common cancers and have not improved over time. Tadalaf...

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Vydáno v:Sci Rep
Hlavní autoři: Lawless, Michael, Caldwell, Jessica L., Radcliffe, Emma J., Smith, Charlotte E. R., Madders, George W. P., Hutchings, David C., Woods, Lori S., Church, Stephanie J., Unwin, Richard D., Kirkwood, Graeme J., Becker, Lorenz K., Pearman, Charles M., Taylor, Rebecca F., Eisner, David A., Dibb, Katharine M., Trafford, Andrew. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494852/
https://ncbi.nlm.nih.gov/pubmed/31043634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42592-1
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